High-Fat and Ketogenic Diets in Amyotrophic Lateral Sclerosis (ALS)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438106/

”In summary, there are strong epidemiologic data showing that malnutrition is a common symptom of amyotrophic lateral sclerosis both in humans and in mice and may contribute to disease progression. There is also epidemiologic evidence that increased dietary fat and cholesterol intake might reduce the risk of amyotrophic lateral sclerosis and the rate disease progression. Finally, data from animal studies strongly suggest that increasing dietary intake of fat ameliorates disease progression (Paganoni & Wills
2013).”

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Paganoni, S. & Wills, A. M. (2013). High-fat and ketogenic diets in amyotrophic lateral sclerosis. J Child Neurol, 28(8), ss. 989-992.
DOI:10.1177/0883073813488669

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Alternative Fuels in Epilepsy and Amyotrophic Lateral Sclerosis (ALS)

https://www.ncbi.nlm.nih.gov/pubmed/27868154

”In both epilepsy and ALS, there are defects in glucose uptake and reduced tricarboxylic acid
(TCA) cycling, at least in part due to reduced amounts of C4 TCA cycle intermediates. In addition there are impairments in glycolysis in ALS. A reduction in glucose uptake can be addressed by providing the brain with alternative fuels, such as ketones or medium-chain triglycerides (Tefera et al. 2017).”

Alternative Fuels in Epilepsy and Amyotrophic Lateral Sclerosis. – PubMed – NCBI: Neurochem Res. 2017 Jun;42(6):1610-1620. doi: 10.1007/s11064-016-2106-7. Epub 2016 Nov 21.

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Can ketogenic diet slow progression of ALS? – The Lancet Neurology

http://www.thelancet.com/pdfs/journals/laneur/PIIS1474-4422(06)70462-8.pdf

”For the first time, researchers have shown that diet can alter the
progression of amyotrophic lateral sclerosis (ALS) in a mouse model of
the disease (Siva 2006).”

Can ketogenic diet slow progression of ALS?
Siva, Nayanah
The Lancet Neurology , Volume 5 , Issue 6 , 476

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Ketogenic diet in pyruvate dehydrogenase complex deficiency: short- and long-term outcomes | SpringerLink

http://ift.tt/2k2yLHd

Conclusion

Ketogenic diet was an effective and safe treatment for the majority of patients. Treatment effect was mainly determined by disease phenotype and attainment and maintenance of ketosis.

Sofou, K., Dahlin, M., Hallböök, T. et al. J Inherit Metab Dis (2017). doi:10.1007/s10545-016-0011-5

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Nutritional Ketosis Condition and Specific Ketogenic Diet, May Benefit Cancer Patients as an Alternative Treatment by Sudden Change in the Metabolic State of Cancer Cells. | Niknamian | International Science and Investigation journal

http://ift.tt/2hSZIeP

Abstract

Cancer disease is the second cause of death in the United States and world-wide. Most Researchers estimate that 595,690 of American people will die from cancer at the end of the year 2017. That means 1,600 deaths/day approximately.³⁹ Cancer in modern societies is commonly treated with the combination of organ surgery, chemotherapy and radiotherapy. Many kinds of diet strategies have been experimented. However, none of them have been particularly effective. Interestingly, there is some applied research suggesting that a very low-carb, high fat diet may help.^{40, 41, 42} According to Otto Warburg hypothesis, the cause of cancer is the change in the metabolism of mitochondrion in human cells. Low oxygen in tissues in combination with high blood glucose will change the cell respiration from aerobic to anaerobic which leads to fermentation type of respiration. In this perspective and prospective research, I have shown the very low carbohydrate ketogenic diet and mostly ketosis, may benefit cancer patients in reducing and weakening cancer cells. Although further researches are needed, this perspective article could be beneficial in future perspective of alternative treatments of cancer.

Niknamian, S. (2016). Nutritional Ketosis Condition and Specific Ketogenic Diet, May Benefit Cancer Patients as an Alternative Treatment by Sudden Change in the Metabolic State of Cancer Cells.. International Science And Investigation Journal, 5(5), 28-48. Retrieved from http://ift.tt/2hSZIeP

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The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis

http://ift.tt/2gdBKXO

Abstract

Until recently, multiple sclerosis has been viewed as an entirely inflammatory disease without acknowledgment of the significant neurodegenerative component responsible for disease progression and disability. This perspective is being challenged by observations of a dissociation between inflammation and neurodegeneration where the neurodegenerative component may play a more significant role in disease progression. In this review, we explore the relationship between mitochondrial dysfunction and neurodegeneration in multiple sclerosis. We review evidence that the ketogenic diet can improve mitochondrial function and discuss the potential of the ketogenic diet in treating progressive multiple sclerosis for which no treatment currently exists.

Storoni M, Plant GT. The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis. Multiple Sclerosis International. 2015;2015:681289. doi:10.1155/2015/681289.

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Targeting insulin inhibition as a metabolic therapy in advanced cancer: a pilot safety and feasibility dietary trial in 10 patients. – PubMed – NCBI

http://ift.tt/29gUou3

CONCLUSION: Preliminary data demonstrate that an insulin-inhibiting diet is safe and feasible in selected patients with advanced cancer. The extent of ketosis, but not calorie deficit or weight loss, correlated with stable disease or partial remission.

Nutrition. 2012 Oct;28(10):1028-35. doi: 10.1016/j.nut.2012.05.001. Epub 2012 Jul 26.

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FULL TEXT – A child with type 1 diabetes mellitus (T1DM) successfully treated with the Paleolithic ketogenic diet: A 19-month insulin freedom – International Journal of Case Reports and Images (IJCRI)

http://ift.tt/1QQhUkG

Conclusion: We opine that the Paleolithic ketogenic diet ensure normal glucose levels and can be maintained on the long-term in those patients with newly diagnosed T1DM with residual insulin secretion. It is important to emphasize, however, that in those patients with long-standing T1DM beta cells might have exhausted and therefore there may be a need for insulin replacement. In these cases, however, the Paleolithic ketogenic diet may be used as an adjunct in an attempt to likely prevent diabetic complications.

Tóth C, Clemens Z. A child with type 1 diabetes mellitus (T1DM) successfully treated with the Paleolithic ketogenic diet: A 19-month insulin freedom. Int J Case Rep Images 2015;6(12):753–758.

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Dominic D’Agostino: Metabolic Therapies: Therapeutic Implications and Practical Application

http://ift.tt/1avCbsY

Metabolic therapies that induce a state of mild ketosis from caloric restriction or the ketogenic diet offer neuroprotection against a wide range of pathologies, and continues to be an emerging strategy for the metabolic management of cancer. Severe dietary restriction of calories or carbohydrates is typically needed to produce a level of ketosis that achieves therapeutic benefits. Interestingly, the strategy to use exogenous ketones as an alternative fuel has not been exploited therapeutically. When administered orally in controlled dosages, ketone esters and other ketogenic agents can lower glucose and elevate plasma ketone levels comparable to levels achieved by the most rigorous ketogenic diets. Metabolic therapies in the form of ketone supplementation offer a safe, convenient, and versatile new treatment approach for a variety of diseases, including seizure disorders, neurodegenerative diseases and cancer.

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Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: A pilot trial

http://ift.tt/1yuPHIQ

Conclusions: 

These pilot data suggest that a Ketogenic Diet is suitable for even advanced cancer patients. It has no severe side effects and might improve aspects of quality of life and blood parameters in some patients  with advanced metastatic tumors.

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