Association Between Soft Drink Consumption and Mortality in 10 European Countries | Cardiology | JAMA Internal Medicine | JAMA Network

https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2749350

Conclusions and Relevance: This study found that consumption of total, sugar-sweetened, and artificially sweetened soft drinks was positively associated with all-cause deaths in this large European cohort; the results are supportive of public health campaigns aimed at limiting the consumption of soft drinks.

Mullee A, Romaguera D, Pearson-Stuttard J, et al. Association Between
Soft Drink Consumption and Mortality in 10 European Countries. JAMA Intern Med. 2019;179(11):1479–1490. doi:10.1001/jamainternmed.2019.2478

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Sugary Beverage Consumption and All-Cause Mortality

http://bit.ly/2X53UKm

”Mean sugary beverage consumption was 8.4% of total calories, split roughly equally between sugar-sweetened beverages and 100% fruit juice (which are essentially identical in sugar content).”

”For example, high consumption of sugary beverages” …

”was associated with 44% higher risk for CHD-related death. The relative risk for all-cause mortality increased by 24% for every additional 12-ounce consumption of 100% fruit juice.”

Collin LJ et al. Association of sugary beverage consumption with mortality risk in US adults: A secondary analysis of data from the REGARDS study. JAMA Netw Open 2019 May 3; 2:e193121. (https://doi.org/10.1001/jamanetworkopen.2019.3121)

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Evidence That Intermittent, Excessive Sugar Intake Causes Endogenous Opioid Dependence – Colantuoni – 2002 – Obesity – Wiley Online Library

http://ift.tt/2Dljlsd

Discussion: Repeated, excessive intake of sugar created a state in which an opioid antagonist caused behavioral and neurochemical signs of opioid withdrawal. The indices of anxiety and DA/ACh imbalance were qualitatively similar to withdrawal from morphine or nicotine, suggesting that the rats had become sugar-dependent.

Colantuoni, C., Rada, P., McCarthy, J., Patten, C., Avena, N. M., Chadeayne, A. and Hoebel, B. G. (2002), Evidence That Intermittent, Excessive Sugar Intake Causes Endogenous Opioid Dependence. Obesity Research, 10: 478–488. doi:10.1038/oby.2002.66

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Effects of Dietary Fructose Restriction on Liver Fat, De Novo Lipogenesis, and Insulin Kinetics in Children With Obesity – Gastroenterology

http://ift.tt/2uRhWAL

”Conclusions
Short-term (9 days) isocaloric fructose restriction decreased liver fat, VAT, and DNL, and improved insulin kinetics in children with obesity. These findings support efforts to reduce sugar consumption. ClinicalTrials.gov Number: NCT01200043.”

Effects of Dietary Fructose Restriction on Liver Fat, De Novo Lipogenesis, and Insulin Kinetics in Children With Obesity

Schwarz, Jean-Marc et al.
Gastroenterology , Volume 153 , Issue 3 , 743 – 752

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Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia | Stroke

http://ift.tt/2oLP7D2

ConclusionsArtificially sweetened soft drink consumption was associated with a higher risk of stroke and dementia.






Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia
Matthew P. Pase, Jayandra J. Himali, Alexa S. Beiser, Hugo J. Aparicio, Claudia L. Satizabal, Ramachandran S. Vasan, Sudha Seshadri and Paul F. Jacques
Stroke. 2017;48:1139-1146, originally published April 24, 2017

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Sugar addiction: pushing the drug-sugar analogy to the limit. – PubMed – NCBI

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Overall, this research has revealed that sugar and sweet reward can not only substitute to addictive drugs, like cocaine, but can even be more rewarding and attractive.”



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