Meaning This review suggests that intermittent fasting may have a beneficial role in improving anthropometric and cardiometabolic outcomes, especially for adults with overweight or obesity.
”Over the course of three months, the mice in the IF group demonstrated
improved long-term memory retention compared to the other groups. When
the brains of these mice were studied, it was apparent that the Klotho
gene was upregulated, and neurogenesis increased compared to those that
were on the CR diet.”
King’s College London. (2021, May 24). Intermittent fasting in mice
effective at promoting long term memory retention: Intermittent fasting
in mice demonstrably more effective at promoting long term memory
retention. ScienceDaily. Retrieved May 27, 2021 from https://ift.tt/3oWJtxP
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Most animals alternate periods of feeding with periods of fasting often coinciding with sleep. Upon >24 hr of fasting, humans, rodents, and other mammals enter alternative metabolic phases, which rely less on glucose and more on ketone body-like carbon sources. Both intermittent and periodic fasting result in benefits ranging from the prevention to the enhanced treatment of diseases. Similarly, time-restricted feeding (TRF), in which food consumption is restricted to certain hours of the day, allows the daily fasting period to last >12 hr, thus imparting pleiotropic benefits. Understanding the mechanistic link between nutrients and the fasting benefits is leading to the identification of fasting-mimicking diets (FMDs) that achieve changes similar to those caused by fasting. Given the pleiotropic and sustained benefits of TRF and FMDs, both basic science and translational research are warranted to develop fasting-associated interventions into feasible, effective, and inexpensive treatments with the potential to improve healthspan.
Longo VD, Panda S. Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan. Cell Metab. 2016 Jun 14;23(6):1048-1059. doi: 10.1016/j.cmet.2016.06.001. PMID: 27304506; PMCID: PMC5388543.
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- First human serum proteomics study of 30-day intermittent fasting from dawn to sunset in healthy subjects
- The 30-day intermittent fasting from dawn to sunset is associated with a serum proteome protective against cancer
- Intermittent fasting from dawn to sunset for 30 days upregulates proteins protective against obesity, diabetes, and metabolic syndrome
- Intermittent fasting from dawn to sunset for 30 days induces key regulatory proteins of DNA repair and immune system
- Intermittent fasting from dawn to sunset for 30 days upregulates proteins protective against Alzheimer’s disease and neuropsychiatric disorders
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