Research Uncovers How Commensal Bacteria Contribute to Multiple Sclerosis | Demyelinating Disorders | JAMA | JAMA Network

https://jamanetwork.com/journals/jama/fullarticle/2695647?guestAccessKey=b3c0e1a2-d206-4df0-8bce-2d938a392652

”These findings suggest inhibitors of VEGF-B–FLT-1 signaling or agonists of TGF-α–ErbB1 signaling may represent promising anti-inflammatory and neuroprotective therapies for MS and possibly other neurodegenerative diseases. Diets that promote anti-inflammatory pathways could be a noninvasive approach to treating brain inflammation”

Hampton T. Research Uncovers How Commensal Bacteria Contribute to Multiple Sclerosis. JAMA. 2018;320(5):429–430. doi:10.1001/jama.2017.12863

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Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation. – PubMed – NCBI

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FINDINGS: Various afferent or efferent pathways are involved in the MGB axis. Antibiotics, environmental and infectious agents, intestinal neurotransmitters/neuromodulators, sensory vagal fibers, cytokines, and essential metabolites all convey information to the central nervous system about the intestinal state. Conversely, the hypothalamic-pituitary-adrenal axis, the central nervous system regulatory areas of satiety, and neuropeptides released from sensory nerve fibers affect the gut microbiota composition directly or through nutrient availability. Such interactions seem to influence the pathogenesis of a number of disorders in which inflammation is implicated, such as mood disorder, autism-spectrum disorders, attention-deficit hypersensitivity disorder, multiple sclerosis, and obesity.

Clin Ther. 2015 May 1;37(5):984-95. doi: 10.1016/j.clinthera.2015.04.002.

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The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis

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Abstract

Until recently, multiple sclerosis has been viewed as an entirely inflammatory disease without acknowledgment of the significant neurodegenerative component responsible for disease progression and disability. This perspective is being challenged by observations of a dissociation between inflammation and neurodegeneration where the neurodegenerative component may play a more significant role in disease progression. In this review, we explore the relationship between mitochondrial dysfunction and neurodegeneration in multiple sclerosis. We review evidence that the ketogenic diet can improve mitochondrial function and discuss the potential of the ketogenic diet in treating progressive multiple sclerosis for which no treatment currently exists.

Storoni M, Plant GT. The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis. Multiple Sclerosis International. 2015;2015:681289. doi:10.1155/2015/681289.

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