Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness

https://pubmed.ncbi.nlm.nih.gov/35113901/

Conclusions: Among hospitalized COVID-19 patients, pre-infection deficiency of vitamin D was associated with increased disease severity and mortality.”

Dror AA, Morozov N, Daoud A, Namir Y, Yakir O, Shachar Y, Lifshitz M, Segal E, Fisher L, Mizrachi M, Eisenbach N, Rayan D, Gruber M, Bashkin A, Kaykov E, Barhoum M, Edelstein M, Sela E. Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness. PLoS One. 2022 Feb 3;17(2):e0263069. doi: 10.1371/journal.pone.0263069. PMID: 35113901; PMCID: PMC8812897.

Annons

Association between vitamin D status and risk of covid-19 in-hospital mortality: A systematic review and meta-analysis of observational studies

https://pubmed.ncbi.nlm.nih.gov/34882024/

”We found a significant direct association between vitamin D deficiency and elevated risk of COVID-19 in-hospital mortality. Moreover, each unit increment in serum vitamin D levels was associated to significant reduction in risk of COVID-19 mortality.”

Ebrahimzadeh A, Mohseni S, Narimani B, Ebrahimzadeh A, Kazemi S, Keshavarz F, Yaghoubi MJ, Milajerdi A. Association between vitamin D status and risk of covid-19 in-hospital mortality: A systematic review and meta-analysis of observational studies. Crit Rev Food Sci Nutr. 2021 Dec 9:1-11. doi: 10.1080/10408398.2021.2012419. Epub ahead of print. PMID: 34882024.

Påverkar vitaminer och metaboliter risken för ö-cellsautoantikroppar och utveckling av diabetes? 2021

https://www.teddy.lu.se/resultat-fran-teddy/alla-forskningsartiklar-indelade-i-amnen/autoantikroppar/paverkar-vitaminer-och-metaboliter-risken-o-cellsautoantikroppar-och-utveckling-av-diabetes-2021

Frågeställningen i studien var om ämnesomsättningsprodukter så kallade metaboliter (aminosyror, fettsyror med mera) och vitaminer (vitamin C och D) i plasma var förändrade före det att en första autoantikropp utvecklades.

  • Resultatet från studien visar att barn som fick IAA som första autoantikropp vid ett års ålder hade låga nivåer av vitamin C och kolesterol före det att IAA utvecklades.
  • Lite äldre barn som fick GADA som första autoantikropp visade sig ha låga nivåer av sfingomyelin, en fosfolipid som finns i mjölkfett och som är mycket viktig för immunsystemet men också för hjärnans celler, centrala nervsystemet samt den neurologiska utvecklingen.
  • De barn som utvecklade antingen IAA eller GADA som första autoantikropp och hade låga nivåer av vitamin D, hade störst risk att få en andra autoantikropp och att utveckla diabetes på kort tid. Barn med GADA som första autoantikropp hade också låga plasmanivåer av diglycerider, lysofosfatidylkolin, triglycerider och alanin, vilket ökade deras risk att utveckla en andra autoantikropp och diabetes.

Studien visar att låga nivåer av både vitamin D och C ökade risken att utveckla en första autoantikropp. Andra biomarkörer hade också låga nivåer före uppkomsten av den första autoantikroppen. 

TEDDY har kunnat påvisa att vanliga enterovirusinfektioner kan trigga en första autoantikropp hos vissa men inte alla barn. Låga nivåer av vitamin D och C samt andra metaboliter tycks kunna bidra till att en virusinfektion utvecklar diabetes hos barn.

Vitamin D and Lung Outcomes in Elderly COVID-19 Patients

 https://pubmed.ncbi.nlm.nih.gov/33668240/

 Conclusions: This study confirms that 25OH-vitamin D serum deficiency is associated with more severe lung involvement, longer disease duration and risk of death, in elderly COVID-19 patients. The detection of low vitamin D levels also in younger COVID-19 patients with less comorbidities further suggests vitamin D deficiency as crucial risk factor at any age.

Sulli A, Gotelli E, Casabella A, Paolino S, Pizzorni C, Alessandri E, Grosso M, Ferone D, Smith V, Cutolo M. Vitamin D and Lung Outcomes in Elderly COVID-19 Patients. Nutrients. 2021 Feb 24;13(3):717. doi: 10.3390/nu13030717. PMID: 33668240; PMCID: PMC7996150.

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“Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study” – ScienceDirect

https://www.sciencedirect.com/science/article/pii/S0960076020302764?via%3Dihub

Conclusion

”Our
pilot study demonstrated that administration of a high dose of
Calcifediol or 25-hydroxyvitamin D, a main metabolite of vitamin D
endocrine system, significantly reduced the need for ICU treatment of
patients requiring hospitalization due to proven COVID-19.”
 
 Entrenas Castillo, M., Entrenas Costa, L. M., Vaquero Barrios, J. M., Alcalá Díaz, J. F., López Miranda, J., Bouillon, R. & Quesada Gomez, J. M. (2020). “Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study”. The Journal of Steroid Biochemistry and Molecular Biology, 203, s. 105751. doi:https://ift.tt/3o1kOa0

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Evidence That Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths – PubMed

https://pubmed.ncbi.nlm.nih.gov/32252338/

”To reduce the risk of infection, it is recommended that people at risk of influenza and/or COVID-19 consider taking 10,000 IU/d of vitamin D3 for a few weeks to rapidly raise 25(OH)D concentrations, followed by 5000 IU/d. The goal should be to raise 25(OH)D concentrations above 40-60 ng/mL (100-150 nmol/L).”

Grant WB, Lahore H,
McDonnell SL, et al. Evidence that Vitamin D Supplementation Could
Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients. 2020;12(4):E988. Published 2020 Apr 2. doi:10.3390/nu12040988

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Estimated intake of vitamin D and its interaction with vitamin A on lung cancer risk among smokers

http://ift.tt/2bLYS12

Total vitamin D intake ≥400 versus <400 IU/d was associated with a lower risk of total lung cancer among participants who received the CARET active intervention (HR=0.56, 95% CI=0.32–0.99) and among those who had total vitamin A intake ≥1,500 μg/d Retinol Activity Equivalent (RAE; HR=0.46, 95% CI=0.23–0.91). The beneficial associations were attenuated among those who did not receive the CARET active intervention or who had total vitamin A intake <1,500 μg/d RAE (P-interaction=0.02 for current smokers). Our observation suggests that vitamin A may assist vitamin D in preventing lung cancer among smokers.





Cheng T-YD, Goodman GE, Thornquist MD, et al. Estimated intake of vitamin D and its interaction with vitamin A on lung cancer risk among smokers.International journal of cancer Journal international du cancer. 2014;135(9):2135-2145. doi:10.1002/ijc.28846.




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