A drug that can stop tumors from growing — ScienceDaily

https://www.sciencedaily.com/releases/2021/04/210407174307.htm

 

Summary:
Scientists detail new work on NLRP3, an
intracellular complex that has been found to participate in
melanoma-mediated inflammation, leading to tumor growth and progression.
By inhibiting NLRP3, the researchers found, they can reduce
inflammation and the resultant tumor expansion.
 

 

 University of Colorado Anschutz Medical Campus. (2021, April 7). A drug that can stop tumors from growing. ScienceDaily. Retrieved May 16, 2021 from https://ift.tt/3huYIfI

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A low carbohydrate, high protein diet slows tumor growth and prevents cancer initiation

 https://pubmed.ncbi.nlm.nih.gov/21673053/

 Strikingly, in a genetically engineered mouse model of HER-2/neu-induced mammary cancer, tumor penetrance in mice on a Western diet was nearly 50% by the age of 1 year whereas no tumors were detected in mice on the low CHO diet. This difference was associated with weight gains in mice on the Western diet not observed in mice on the low CHO diet.”

 Taken together, our findings offer a compelling preclinical illustration of the ability of a low CHO diet in not only restricting weight gain but also cancer development and progression”


Ho VW, Leung K, Hsu A, Luk B, Lai J, Shen SY, Minchinton AI, Waterhouse D, Bally MB, Lin W, Nelson BH, Sly LM, Krystal G. A low carbohydrate, high protein diet slows tumor growth and prevents cancer initiation. Cancer Res. 2011 Jul 1;71(13):4484-93. doi: 10.1158/0008-5472.CAN-10-3973. Epub 2011 Jun 14. PMID: 21673053.


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Is the restricted ketogenic diet a viable alternative to the standard of care for managing malignant brain cancer? – PubMed

https://pubmed.ncbi.nlm.nih.gov/21885251/

 

Abstract

Malignant brain cancer persists as a major disease of morbidity
and mortality. The failure to recognize brain cancer as a disease of
energy metabolism has contributed in large part to the failure in
management. As long as brain tumor cells have access to glucose and
glutamine, the disease will progress. The current standard of care
provides brain tumors with access to glucose and glutamine. The high fat
low carbohydrate ketogenic diet (KD) will target glucose availability
and possibly that of glutamine when administered in carefully restricted
amounts to reduce total caloric intake and circulating levels of
glucose. The restricted KD (RKD) targets major signaling pathways
associated with glucose and glutamine metabolism including the
IGF-1/PI3K/Akt/Hif pathway. The RKD is anti-angiogenic, anti-invasive,
anti-inflammatory, and pro-apoptotic when evaluated in mice with
malignant brain cancer. The therapeutic efficacy of the restricted KD
can be enhanced when combined with drugs that also target glucose and
glutamine. Therapeutic efficacy of the RKD was also seen against
malignant gliomas in human case reports. Hence, the RKD can be an
effective non-toxic therapeutic option to the current standard of care
for inhibiting the growth and invasive properties of malignant brain
cancer.

 

Seyfried TN, Marsh
J, Shelton LM, Huysentruyt LC, Mukherjee P. Is the restricted ketogenic
diet a viable alternative to the standard of care for managing malignant
brain cancer? Epilepsy Res. 2012 Jul;100(3):310-26. doi:
10.1016/j.eplepsyres.2011.06.017. Epub 2011 Aug 31. PMID: 21885251.

 

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Red Meat Intake and Cardiometabolic and Cancer Outcomes | Annals of Internal Medicine | American College of Physicians

https://ift.tt/2IfVDOn

Conclusion:
Low- to very-low-certainty evidence suggests that diets restricted in red meat may have little or no effect on major cardiometabolic outcomes and cancer mortality and incidence.

Zeraatkar D, Johnston BC, Bartoszko J, et al. Effect of Lower Versus Higher Red Meat Intake on Cardiometabolic and Cancer OutcomesA Systematic Review of Randomized Trials. Ann Intern Med. 2019; [Epub ahead of print 1 October 2019]. doi: 10.7326/M19-0622

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No effect of 600 grams fruit and vegetables per day on oxidative DNA damage and repair in healthy nonsmokers. – PubMed – NCBI

https://ift.tt/2Faex74

”In several epidemiological studies, high intakes of fruits and vegetables have been associated with a lower incidence of cancer. Theoretically, intake of antioxidants by consumption of fruits and vegetables should protect against reactive oxygen species and decrease the formation of oxidative DNA damage.”

Our results show that after 24 days of complete depletion of fruits and vegetables, or daily ingestion of 600 g of fruit and vegetables, or the corresponding amount of vitamins and minerals, the level of oxidative DNA damage was unchanged.”



Cancer Epidemiol Biomarkers Prev. 2003 Oct;12(10):1016-22.

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Consumption of ultra-processed foods and cancer risk: results from NutriNet-Santé prospective cohort | The BMJ

http://www.bmj.com/content/360/bmj.k322

”Conclusions In this large prospective study, a 10%
increase in the proportion of ultra-processed foods in the diet was
associated with a significant increase of greater than 10% in risks of
overall and breast cancer (Fiolet et al. 2018).”

Fiolet, T., Srour,
B., Sellem, L., Kesse-Guyot, E., Alles, B., Mejean, C., Deschasaux, M.,
Fassier, P., Latino-Martel, P., Beslay, M., Hercberg, S., Lavalette, C.,
Monteiro, C. A., Julia, C. & Touvier, M. (2018). Consumption of
ultra-processed foods and cancer risk: results from NutriNet-Sante prospective
cohort. BMJ, 360, s. k322. DOI:10.1136/bmj.k322

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Nutrition and Health – The Association between Eating Behavior and Various Health Parameters: A Matched Sample Study

http://ift.tt/2rC7MXB

”Our results showed that a vegetarian diet is associated with poorer health (higher incidences of cancer, allergies, and mental health disorders), a higher need for health care, and poorer quality of life. Therefore, public health programs are needed in order to reduce the health risk due to nutritional factors.”



Burkert NT, Muckenhuber J, Großschädl F, Rásky É, Freidl W.
Nutrition and Health – The Association between Eating Behavior and Various
Health Parameters: A Matched Sample Study. Gorlova OY, ed. 
PLoS ONE. 2014;9(2):e88278. doi:10.1371/journal.pone.0088278.

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Press-pulse: a novel therapeutic strategy for the metabolic management of cancer | Nutrition & Metabolism | Full Text

http://ift.tt/2wja0c6

”Conclusions

Optimization of dosing, timing, and scheduling of the press-pulse therapeutic strategy will facilitate the eradication of tumor cells with minimal patient toxicity. This therapeutic strategy can be used as a framework for the design of clinical trials for the non-toxic management of most cancers.”
Press-pulse: a novel therapeutic strategy for the metabolic management of cancerThomas N. SeyfriedEmail author, George Yu, Joseph C. Maroon and Dominic P. D’AgostinoNutrition & Metabolism201714:19http://ift.tt/2vqx5xq  The Author(s). 2017Received: 29 September 2016Accepted: 17 February 2017Published: 23 February 2017
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Vegetable Oils Consumption as One of the Leading Cause of Cancer and Heart Disease | Niknamian | International Science and Investigation journal

http://ift.tt/2kA7QCM

Abstract

This review takes a deep look at increases in the incidence of cancer and heart disease after
the introduction of industrial vegetable oils in the world. Most vegetable oils are highly
processed and refined products, which completely lack the essential nutrients. Omega-6
Linoleic acid from vegetable oils increases oxidative stress in the body of humans, contributing
to endothelial dysfunction and heart disease. The consumption of these harmful oils which are
high in mega-6 polyunsaturated fats results in changing the structure of cell membrane which
contribute to increasing inflammation and the incidence of cancer.

Niknamian, S., & Kalamian, M. (2016). Vegetable Oils Consumption as One of the Leading Cause of Cancer and Heart Disease. International Science And Investigation Journal, 5(5), 157-168. Retrieved from http://ift.tt/2kA7QCM

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Estimated intake of vitamin D and its interaction with vitamin A on lung cancer risk among smokers

http://ift.tt/2bLYS12

Total vitamin D intake ≥400 versus <400 IU/d was associated with a lower risk of total lung cancer among participants who received the CARET active intervention (HR=0.56, 95% CI=0.32–0.99) and among those who had total vitamin A intake ≥1,500 μg/d Retinol Activity Equivalent (RAE; HR=0.46, 95% CI=0.23–0.91). The beneficial associations were attenuated among those who did not receive the CARET active intervention or who had total vitamin A intake <1,500 μg/d RAE (P-interaction=0.02 for current smokers). Our observation suggests that vitamin A may assist vitamin D in preventing lung cancer among smokers.





Cheng T-YD, Goodman GE, Thornquist MD, et al. Estimated intake of vitamin D and its interaction with vitamin A on lung cancer risk among smokers.International journal of cancer Journal international du cancer. 2014;135(9):2135-2145. doi:10.1002/ijc.28846.




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