High-Fat and Ketogenic Diets in Amyotrophic Lateral Sclerosis (ALS)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438106/

”In summary, there are strong epidemiologic data showing that malnutrition is a common symptom of amyotrophic lateral sclerosis both in humans and in mice and may contribute to disease progression. There is also epidemiologic evidence that increased dietary fat and cholesterol intake might reduce the risk of amyotrophic lateral sclerosis and the rate disease progression. Finally, data from animal studies strongly suggest that increasing dietary intake of fat ameliorates disease progression (Paganoni & Wills
2013).”

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Paganoni, S. & Wills, A. M. (2013). High-fat and ketogenic diets in amyotrophic lateral sclerosis. J Child Neurol, 28(8), ss. 989-992.
DOI:10.1177/0883073813488669

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Alternative Fuels in Epilepsy and Amyotrophic Lateral Sclerosis (ALS)

https://www.ncbi.nlm.nih.gov/pubmed/27868154

”In both epilepsy and ALS, there are defects in glucose uptake and reduced tricarboxylic acid
(TCA) cycling, at least in part due to reduced amounts of C4 TCA cycle intermediates. In addition there are impairments in glycolysis in ALS. A reduction in glucose uptake can be addressed by providing the brain with alternative fuels, such as ketones or medium-chain triglycerides (Tefera et al. 2017).”

Alternative Fuels in Epilepsy and Amyotrophic Lateral Sclerosis. – PubMed – NCBI: Neurochem Res. 2017 Jun;42(6):1610-1620. doi: 10.1007/s11064-016-2106-7. Epub 2016 Nov 21.

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Can ketogenic diet slow progression of ALS? – The Lancet Neurology

http://www.thelancet.com/pdfs/journals/laneur/PIIS1474-4422(06)70462-8.pdf

”For the first time, researchers have shown that diet can alter the
progression of amyotrophic lateral sclerosis (ALS) in a mouse model of
the disease (Siva 2006).”

Can ketogenic diet slow progression of ALS?
Siva, Nayanah
The Lancet Neurology , Volume 5 , Issue 6 , 476

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