Påverkar vitaminer och metaboliter risken för ö-cellsautoantikroppar och utveckling av diabetes? 2021

https://www.teddy.lu.se/resultat-fran-teddy/alla-forskningsartiklar-indelade-i-amnen/autoantikroppar/paverkar-vitaminer-och-metaboliter-risken-o-cellsautoantikroppar-och-utveckling-av-diabetes-2021

Frågeställningen i studien var om ämnesomsättningsprodukter så kallade metaboliter (aminosyror, fettsyror med mera) och vitaminer (vitamin C och D) i plasma var förändrade före det att en första autoantikropp utvecklades.

  • Resultatet från studien visar att barn som fick IAA som första autoantikropp vid ett års ålder hade låga nivåer av vitamin C och kolesterol före det att IAA utvecklades.
  • Lite äldre barn som fick GADA som första autoantikropp visade sig ha låga nivåer av sfingomyelin, en fosfolipid som finns i mjölkfett och som är mycket viktig för immunsystemet men också för hjärnans celler, centrala nervsystemet samt den neurologiska utvecklingen.
  • De barn som utvecklade antingen IAA eller GADA som första autoantikropp och hade låga nivåer av vitamin D, hade störst risk att få en andra autoantikropp och att utveckla diabetes på kort tid. Barn med GADA som första autoantikropp hade också låga plasmanivåer av diglycerider, lysofosfatidylkolin, triglycerider och alanin, vilket ökade deras risk att utveckla en andra autoantikropp och diabetes.

Studien visar att låga nivåer av både vitamin D och C ökade risken att utveckla en första autoantikropp. Andra biomarkörer hade också låga nivåer före uppkomsten av den första autoantikroppen. 

TEDDY har kunnat påvisa att vanliga enterovirusinfektioner kan trigga en första autoantikropp hos vissa men inte alla barn. Låga nivåer av vitamin D och C samt andra metaboliter tycks kunna bidra till att en virusinfektion utvecklar diabetes hos barn.

In Alzheimer Research, Glucose Metabolism Moves to Center Stage

https://jamanetwork.com/journals/jama/fullarticle/2758712

”Six weeks after completing the modified ketogenic diet, patients had improved Alzheimer disease biomarkers in their cerebrospinal fluid. “With the ketogenic diet, we are moving the β-amyloid in a healthier direction,” Craft said. Patients also had better blood flow to the hippocampus and improved body-wide insulin sensitivity. A larger trial of the modified ketogenic diet is now under way.”


Kuehn BM. In Alzheimer Research, Glucose Metabolism Moves to Center Stage. JAMA.2020;323(4):297–299. doi:10.1001/jama.2019.20939


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Low-carb diet may reduce diabetes risk independent of weight loss: Researchers report reversal of metabolic syndrome in some cases — ScienceDaily

https://www.sciencedaily.com/releases/2019/06/190620100036.htm

Low-carb diet may reduce diabetes risk independent of weight loss: Researchers report reversal of metabolic syndrome in some cases

Ohio State University. (2019, June 20). Low-carb diet may reduce diabetes risk independent of weight loss: Researchers report reversal of metabolic syndrome in some cases. ScienceDaily. Retrieved June 30, 2019 from https://ift.tt/2RLaq7c

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FULL TEXT – A child with type 1 diabetes mellitus (T1DM) successfully treated with the Paleolithic ketogenic diet: A 19-month insulin freedom – International Journal of Case Reports and Images (IJCRI)

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Conclusion: We opine that the Paleolithic ketogenic diet ensure normal glucose levels and can be maintained on the long-term in those patients with newly diagnosed T1DM with residual insulin secretion. It is important to emphasize, however, that in those patients with long-standing T1DM beta cells might have exhausted and therefore there may be a need for insulin replacement. In these cases, however, the Paleolithic ketogenic diet may be used as an adjunct in an attempt to likely prevent diabetic complications.







Tóth C, Clemens Z. A child with type 1 diabetes mellitus (T1DM) successfully treated with the Paleolithic ketogenic diet: A 19-month insulin freedom. Int J Case Rep Images 2015;6(12):753–758.

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Personalized Nutrition by Prediction of Glycemic Responses: Cell

http://ift.tt/1T3LYYu

Summary

Elevated postprandial blood glucose levels constitute a global epidemic and a major risk factor for prediabetes and type II diabetes, but existing dietary methods for controlling them have limited efficacy. Here, we continuously monitored week-long glucose levels in an 800-person cohort, measured responses to 46,898 meals, and found high variability in the response to identical meals, suggesting that universal dietary recommendations may have limited utility. We devised a machine-learning algorithm that integrates blood parameters, dietary habits, anthropometrics, physical activity, and gut microbiota measured in this cohort and showed that it accurately predicts personalized postprandial glycemic response to real-life meals. We validated these predictions in an independent 100-person cohort. Finally, a blinded randomized controlled dietary intervention based on this algorithm resulted in significantly lower postprandial responses and consistent alterations to gut microbiota configuration. Together, our results suggest that personalized diets may successfully modify elevated postprandial blood glucose and its metabolic consequences.

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PLOS ONE: High Intensity Interval Training Improves Glycaemic Control and Pancreatic β Cell Function of Type 2 Diabetes Patients

http://ift.tt/1Pi0nhS

Abstract

Physical activity improves the regulation of glucose homeostasis in both type 2 diabetes (T2D) patients and healthy individuals, but the effect on pancreatic β cell function is unknown. We investigated glycaemic control, pancreatic function and total fat mass before and after 8 weeks of low volume high intensity interval training (HIIT) on cycle ergometer in T2D patients and matched healthy control individuals. Study design/method: Elderly (56 yrs±2), non-active T2D patients (n = 10) and matched (52 yrs±2) healthy controls (CON) (n = 13) exercised 3 times (10×60 sec. HIIT) a week over an 8 week period on a cycle ergometer. Participants underwent a 2-hour oral glucose tolerance test (OGTT). On a separate day, resting blood pressure measurement was conducted followed by an incremental maximal oxygen uptake (O2max) cycle ergometer test. Finally, a whole body dual X-ray absorptiometry (DXA) was performed. After 8 weeks of training, the same measurements were performed. Results: in the T2D-group, glycaemic control as determined by average fasting venous glucose concentration (p = 0.01), end point 2-hour OGTT (p = 0.04) and glycosylated haemoglobin (p = 0.04) were significantly reduced. Pancreatic homeostasis as determined by homeostatic model assessment of insulin resistance (HOMA-IR) and HOMA β cell function (HOMA-%β) were both significantly ameliorated (p = 0.03 and p = 0.03, respectively). Whole body insulin sensitivity as determined by the disposition index (DI) was significantly increased (p = 0.03). During OGTT, the glucose continuum was significantly reduced at -15 (p = 0.03), 30 (p = 0.03) and 120 min (p = 0.03) and at -10 (p = 0.003) and 0 min (p = 0.003) with an additional improvement (p = 0.03) of its 1stphase (30 min) area under curve (AUC). Significant abdominal fat mass losses were seen in both groups (T2D: p = 0.004 and CON: p = 0.02) corresponding to a percentage change of -17.84%±5.02 and -9.66%±3.07, respectively. Conclusion: these results demonstrate that HIIT improves overall glycaemic control and pancreatic β cell function in T2D patients. Additionally, both groups experienced abdominal fat mass losses. These findings demonstrate that HIIT is a health beneficial exercise strategy in T2D patients.

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Perinatal risk factors increase the risk of being affected by both type 1 diabetes and coeliac disease. – PubMed – NCBI

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CONCLUSION:

The increased risk of being affected by a double diagnosis of type 1 diabetes and coeliac disease was modulated by perinatal risk factors. This suggests that early life events are important when it comes to children with type 1 diabetes also developing coeliac disease.

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Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy. – PubMed – NCBI

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Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy.

Nix WA, Zirwes R, Bangert V, Kaiser RP, Schilling M, Hostalek U, Obeid R.

Diabetes Res Clin Pract. 2015 Jan;107(1):157-65. doi: 10.1016/j.diabres.2014.09.058. Epub 2014 Oct 8.

PMID: 25458341

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Entropy | Free Full-Text | Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases

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Glyphosate, the active ingredient in Roundup®, is the most popular herbicide used worldwide….

Consequences are most of the diseases and conditions associated with a Western diet, which include gastrointestinal disorders, obesity, diabetes, heart disease, depression, autism, infertility, cancer and Alzheimer’s disease. We explain the documented effects of glyphosate and its ability to induce disease, and we show that glyphosate is the “textbook example” of exogenous semiotic entropy: the disruption of homeostasis by environmental toxins.

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A long-term study conducted on rats showed remarkable pathologies that became apparent only after the three-month period that is usually allotted for toxicity trials. In this experiment, rats were monitored over their entire lifespan, while being fed either genetically modified (GM) or non-GM maize that had been optionally treated with Roundup®. The rats that were chronically exposed to Roundup® developed several pathologies over the course of their lifespan, including large mammary tumors in the females and gastrointestinal, liver and kidney pathologies, especially in the males. The males developed both skin and liver carcinomas. Premature death in the treated male rats was mostly due to severe hepatorenal insufficiencies. Other researchers have shown that oral exposure to glyphosate in drinking water can induce DNA damage to mouse cells drawn from blood and liver…

It is now well established that autism spectrum disorder (ASD) is associated with dysbiosis in the gut….
An increase in short chain fatty acids and ammonia in the gut has been found in association with autism…

Samsel
A, Seneff S. Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid
Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases. 
Entropy. 2013; 15(4):1416-1463.

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