Estimated intake of vitamin D and its interaction with vitamin A on lung cancer risk among smokers

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Total vitamin D intake ≥400 versus <400 IU/d was associated with a lower risk of total lung cancer among participants who received the CARET active intervention (HR=0.56, 95% CI=0.32–0.99) and among those who had total vitamin A intake ≥1,500 μg/d Retinol Activity Equivalent (RAE; HR=0.46, 95% CI=0.23–0.91). The beneficial associations were attenuated among those who did not receive the CARET active intervention or who had total vitamin A intake <1,500 μg/d RAE (P-interaction=0.02 for current smokers). Our observation suggests that vitamin A may assist vitamin D in preventing lung cancer among smokers.





Cheng T-YD, Goodman GE, Thornquist MD, et al. Estimated intake of vitamin D and its interaction with vitamin A on lung cancer risk among smokers.International journal of cancer Journal international du cancer. 2014;135(9):2135-2145. doi:10.1002/ijc.28846.




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Association between vitamin A, retinol intake and blood retinol level and gastric cancer risk: A meta-analysis. – PubMed – NCBI

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”CONCLUSIONS:

Vitamin A intake was inversely associated with gastric cancer risk, while no significant association was found with retinol intake or blood retinol level”
Association between vitamin A, retinol intake and blood retinol level and gastric cancer risk: A meta-analysis.Wu Y, Ye Y, Shi Y, Li P, Xu J, Chen K, Xu E, Yang J.Clin Nutr. 2015 Aug;34(4):620-6. doi: 10.1016/j.clnu.2014.06.007. Epub 2014 Jun 23.PMID: 25008141

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